The contemporary urban lifestyle is linked to long-term, chronic stress, an unfavorable environment, and disturbances in sleep, rest, and diet. Recently, patients with sleep disorders have often been prescribed Zolpidem by doctors of various specialties. However, as practice shows, data concerning its safety are not always taken into account. So, here in this article let’s know the benefits and where to buy zolpidem.
What Is Zolpidem?
The FDA has approved the use of zolpidem, a non-benzodiazepine receptor modulator, as a short-term treatment for insomnia in individuals who have trouble falling asleep. For patients with temporary insomnia, it decreases the frequency of awakenings and enhances sleep latency and duration.
comparable in pharmacological action to benzodiazepines, zolpidem is a hypnotic belonging to the imidazopyridines group. Its effects are qualitatively comparable to those of other medications in this category, including sedatives, muscle relaxants, anxiolytics, anticonvulsants, hypnotics, and amnestic.
Who should not take Zolpidem and when?
● Those with a history of allergic reactions to any of the ingredients in zolpidem.
● Individuals suffering from mental illness, depression, and attempted suicide.
● Patients who use alcohol and drugs.
● For kidney and liver diseases.
● For diseases of the respiratory system.
● During pregnancy or when planning it.
● When breastfeeding.
● The attending physician must be informed about all medications, vitamins, and herbal preparations that the patient uses, as they can interact with each other, leading to undesirable consequences.
How to take Zolpidem?
● The tablets are taken before bedtime. The standard dosage is 10 mg.
● For older people, the initial dosage is 5 mg, then, if necessary, it can be increased to 10 mg.
● The maximum amount of Zolpidem consumed per day is 10 mg.
● The duration of taking the drug is no more than a month.
● Patients with transient insomnia are recommended to take the medicine for 2 to 5 days, for situational insomnia – from 14 to 21 days.
● If treatment is carried out over several days, then taking the drug can be stopped immediately. If the course of treatment lasts more than a week, then the dosage should be reduced gradually to avoid the development of unwanted reactions.
Doses and Route of Administration:
In healthy individuals, zolpidem is quickly absorbed from the gastrointestinal system and has a brief half-life. There are tablets and extended-release tablets for oral zolpidem. Additionally, zolpidem comes in tablet form that can be sublingually inserted beneath the tongue and in spray form that is applied to the tongue. Depending on how well the patient sleeps, 5 or 10 mg oral tablets are given.
The kidneys then transform zolpidem into an inactive metabolite and eliminate it. There is no count for the number of tablets. When used orally, this medication’s effects may be slowed down by eating.
The 5 mg dosage is recommended for elderly patients since larger concentrations have been seen in clinical trials compared to younger adults. Starting at least 7 to 8 hours before your planned wake-up time, the recommended starting dose is 5 mg for women and 5 or 10 mg for males. This dosage should only be taken once a night, right before bedtime. Women have a decreased zolpidem clearance rate.
The patient should consult a doctor if:
● Insomnia symptoms have worsened or remained unchanged. Perhaps the occurrence of insomnia is associated with other factors.
● When using the drug in a larger dose than prescribed by the attending physician.
● Adverse side reactions appeared.
● Zolpidem is not recommended for use without a doctor’s prescription.
It is not recommended to share Zolpidem with others, even if they have similar symptoms of sleep disturbance. This may harm their health.
Overdose Of Zolpidem:
If you abuse the drug Zolpidem or accidentally swallow a large number of tablets, the following may occur: ataxia, confusion, decreased blood pressure, difficulty breathing, lethargy, and even coma.
In case of overdose, it is recommended to induce vomiting as soon as possible (within 60 minutes) and give the victim enterosorbents (Activated carbon). If the patient is unconscious, it is necessary to rinse the stomach through a tube and perform symptomatic therapy. The specific antidote is flumazenil. Dialysis is ineffective. When using flumazenil, the risk of seizures increases, especially in patients with epilepsy.
Interaction:
● Ketoconazole can almost double the half-life of the drug, and the drug can also enhance the effect of central nervous system depression.
● Combining the drug with ethanol can lead to increased sedative effects of the drug and overdose.
Side effects:
● Anaphylaxis, behavioral abnormalities, withdrawal symptoms, and depression of the central nervous system (CNS) are a few of the adverse effects. Rarely, angioedema a swelling of the tongue, larynx, or glottis has been described by patients. In addition, patients complained of nausea, vomiting, and airway obstruction.
● Patients should not receive the medication again if they report this. Patients should be referred to the emergency room if they have a blockage in their larynx, glottis, or throat.
● There have also been reports of unusual thinking and behavioural changes. Furthermore, the patients exhibited extraversion and aggression, which are abnormalities in human behaviour.
● Alcohol or drug toxicity patients reported auditory and visual hallucinations accompanied by agitation and unusual behaviour.
● Additionally, it was discovered that the patient engaged in a behaviour known as “sleep driving,” in which they take a sedative-hypnotic medication and then drive a car while not completely awake and with no memory of the incident.
● These effects have been observed to be amplified by alcohol consumption or any other CNS depressant, as they compound to produce increased sedation. The medicine has to be stopped in these situations. Also, zolpidem shouldn’t be taken by depressed patients since it exacerbates their condition and increases suicidal thoughts and behaviours.
Contraindications:
Only individuals with a documented allergy to the medication or any of the inactive chemicals in the formulation should not use zolpidem. Before writing a zolpidem prescription, it is also important to rule out other potential causes of sleep deficiency, such as a medical or mental health history.
Patients on medications that impact cytochrome P450-mediated drug metabolism should use caution. It may be necessary to prescribe a lower dosage of zolpidem since patients may become more sedated. Furthermore, zolpidem should be avoided by patients who are on imipramine and chlorpromazine. These medications reduce alertness and psychomotor function when taken together.
With zolpidem therapy, depression and/or suicidal thoughts may get worse. Therefore, in order to prevent purposeful zolpidem overdose, doctors should prescribe the fewest number of tablets. When providing zolpidem to patients who have impaired respiratory function, take into account the possibility of respiratory depression. The abrupt reduction or cessation of zolpidem dosage may result in withdrawal symptoms. For this reason, it is advised that long-term zolpidem users gradually taper off their dosage to prevent unneeded withdrawal and negative side effects.
Where To Buy Zolpidem Online?
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Conclusion:
The drug should be prescribed to elderly patients with caution, as they have an increased risk of developing muscle relaxants and soothing effects on the body, which leads to falls and injuries.
